Technical Specifications

Specification	Details
Product Name	MOTS-c
Chemical Name	Mitochondrial Open Reading Frame of the 12S rRNA-c
Strength	20 mg
Molecular Formula	C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight	~2174.6 g/mol
CAS Number	1627580-64-6
Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Sequence Code	MRWQEMGYIFYPRKLR
Sequence Length	16 amino acids
Purity	≥98%
Form	Lyophilized Peptide
Classification	Mitochondrial-Derived Peptide
Intended Use	Laboratory Research Only

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Product Overview

MOTS-c, short for Mitochondrial Open Reading Frame of the 12S rRNA-c, is a naturally occurring 16-amino-acid peptide encoded within the mitochondrial genome.

MOTS-c was identified as a mitochondrial-derived peptide and has been investigated extensively in experimental research involving cellular metabolism, mitochondrial biology, energy homeostasis, stress responses, and metabolic signaling.

Research has examined MOTS-c in cellular and animal models involving glucose utilization, fatty-acid metabolism, AMPK signaling, oxidative-stress responses, and exercise-associated cellular pathways.

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Mechanism of Action

Research has investigated MOTS-c in relation to several biological mechanisms:

AMPK Signaling

Experimental studies have investigated MOTS-c in relation to AMP-activated protein kinase (AMPK), an important cellular energy-sensing pathway involved in metabolic regulation.

Metabolic Regulation

MOTS-c has been studied in experimental models examining glucose utilization, fatty-acid metabolism, and broader cellular metabolic responses.

Mitochondrial Biology

As a mitochondria-derived peptide, MOTS-c provides a research model for investigating communication between mitochondrial genetic information and cellular metabolic processes.

Cellular Stress Response

Experimental research has examined MOTS-c in relation to cellular responses to metabolic and oxidative stress. Research has also investigated its movement into the nucleus under certain cellular stress conditions and associated changes in gene regulation.

Exercise-Related Research

MOTS-c has been investigated in experimental models involving exercise-responsive pathways and skeletal-muscle metabolism.

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Research Applications

MOTS-c may be investigated in laboratory settings involving:

• Mitochondrial-derived peptide research
• Cellular metabolism studies
• AMPK signaling research
• Glucose metabolism research
• Fatty-acid metabolism studies
• Mitochondrial biology
• Oxidative-stress research
• Cellular stress-response studies
• Skeletal-muscle research
• Exercise-associated signaling
• Metabolic pathway research
• Peptide structure-function studies

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Handling & Storage

• Store the lyophilized peptide according to the manufacturer’s recommended conditions.
• Protect from excessive heat, moisture, and direct sunlight.
• Keep the product sealed in its original packaging until required for laboratory research.
• Store at approximately −20°C when consistent with supplier specifications.
• Follow the applicable batch Certificate of Analysis for exact storage requirements.
• Minimize unnecessary temperature fluctuations.
• Avoid repeated freeze-thaw cycles where applicable.
• Protect the material from prolonged exposure to moisture and light.

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Product Features

✓ Research Grade Quality

✓ 20mg Lyophilized Peptide

✓ ≥98% Purity

✓ 16-Amino-Acid Peptide

✓ Mitochondrial-Derived Peptide

✓ MRWQEMGYIFYPRKLR Sequence

✓ Carefully Packaged

✓ Laboratory Research Use Only

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Important Notice

This product is intended exclusively for laboratory research purposes.

It is not intended for human or veterinary use, administration, injection, consumption, diagnosis, treatment, cure, or prevention of any disease.

MOTS-c is an experimental research peptide. Findings from cellular and animal studies involving metabolism, exercise, aging, glucose utilization, or other biological effects should not be interpreted as established evidence of clinical efficacy or safety in humans.

The exact purity, molecular characterization, salt form, and analytical specifications should be verified against the applicable batch Certificate of Analysis (CoA).

By purchasing this product, the purchaser acknowledges that it will be handled only by qualified professionals in appropriate laboratory environments and used in accordance with applicable laws, regulations, and institutional protocols.

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Frequently Asked Questions

What is MOTS-c?

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA.

What does MOTS-c stand for?

MOTS-c stands for Mitochondrial Open Reading Frame of the 12S rRNA-c.

What is the sequence of MOTS-c?

The commonly reported human MOTS-c sequence is:

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

or:

MRWQEMGYIFYPRKLR.

How many amino acids does MOTS-c contain?

MOTS-c is a 16-amino-acid peptide.

What is the molecular weight of MOTS-c?

The reported molecular weight of human MOTS-c is approximately 2174.6 g/mol.

What is MOTS-c researched for?

MOTS-c has been investigated in research involving mitochondrial biology, cellular metabolism, AMPK signaling, glucose utilization, fatty-acid metabolism, oxidative stress, cellular stress responses, and exercise-associated pathways.

Is MOTS-c a mitochondrial protein?

MOTS-c is a mitochondrial-derived peptide, encoded by a short open reading frame within the mitochondrial 12S rRNA region.

What form does MOTS-c 20mg come in?

MOTS-c 20mg is supplied as a lyophilized (freeze-dried) synthetic peptide intended for laboratory research.

What is the purity of MOTS-c?

This product is specified at a minimum purity of ≥98%, subject to the applicable batch Certificate of Analysis.

Is MOTS-c intended for human use?

No. This research-grade product is supplied strictly for laboratory research purposes and is not intended for human or veterinary use.

How should MOTS-c be stored?

The lyophilized peptide should be protected from heat, moisture, and direct sunlight and stored according to the manufacturer’s recommended conditions. Always refer to the batch-specific Certificate of Analysis for exact storage requirements.